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Oxycontin withdrawal symptoms can begin as soon as six hours after the last dose and can last up to one week.4 People who have gone through OxyContin withdrawal compare the process to the intensity of heroin withdrawal: Constant yawning Depression Diarrhea Heart palpitations Hot/cold sweats Insomnia Joint and muscle aches Nausea and vomiting Tiredness or fatigue Uncontrollable coughing Watery eyes, Portland, USA, 97052 (Show me directions) Show Map